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The Post-Injury Knee Arthritis Severity Outcomes (PIKASO) trial is a multi-year, $20 million investment in creating an infrastructure to allow leading Technical description of the Arthritis Foundation-funded randomized clinical trial TOPS (The Osteoarthritis Prevention Study) This manuscript details the design and rationale of a clinical trial of diet and exercise to prevent knee osteoarthritis in female patients over 50 years of age that struggle with obesity. Display your Yankees spirit with officially licensed Yankees jerseys and gear, including shirts, hats and more popular items from the ultimate sports store. We are your NCAA Shop that sells only authentic Collegiate Apparel, including College Football Gear, College Basketball Apparel, NCAA Merchandise, Collegiate Clothing and Gifts. The Arthritis Foundation is committed to making sure patients are involved in the processes and decisions that affect their health and quality of life, including clinical trials. 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